Date: May 14, 2015

New Evidence highlights utility of testing for bacterial protease activity to identify a ‘state of pathogenicity’ that could lead to infection and impair healing


The study of 366 chronic wounds, carried out by Dr. Thomas Serena and The Serena Group of wound care centers in the USA, presented at EWMA in London in May 2015, showed that 49% of chronic wounds were positive for bacterial protease activity, a virulence factor associated with a host invasion and a ‘state of pathogenicity’.

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77% of the wounds that were positive for bacterial protease activity did not have signs of local infection, indicating that testing wound fluid for bacterial protease activity may be a useful method for detecting the presence of pathogenic bacteria, at a clinically significant stage in the infection continuum, even before the signs of infection are apparent.

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