Bacteria are in a pathogenic state when they are either in the process of, or they are capable of, causing disease, i.e. infection. One measure of pathogenicity is the production of enzymatic virulence factors called bacterial proteases1Lebrun I, Marques-Porto R, Pereira AS, Pereira A, Perpetuo EA. Bacterial toxins: an overview on bacterial proteases and their action as virulence factors. Mini-reviews in medicinal chemistry 2009; 9 (7): 820-8.. A number of known proteases have been characterised from some of the frequently reported bacteria in chronic wounds2Koziel J, Potempa J. Protease-armed bacteria in the skin. Cell Tissue Res. 2012; 351(2): 325-37.,3Potempa J, Pike RN. Corruption of innate immunity by bacterial proteases. J. Innate Immun. 2009; 1: 70-87.. The impact of bacterial proteases has been documented in a range of acute and chronic medical conditions, including cystic fibrosis, eye infections and wound infections3Potempa J, Pike RN. Corruption of innate immunity by bacterial proteases. J. Innate Immun. 2009; 1: 70-87.,4Twining SS, Kirschner SE, Mahnke LA, Frank DW. Effect of P aeruginosa elastase, alkaline protease, & exotoxin A on corneal proteinases and proteins. Invest. Ophthalmol. Vis. Sci. 1993; 34(9): 2699-712..
The detection of bacterial protease activity in a chronic wound would be indicative of the presence of bacterial pathogenesis which is a precursor to clinical signs and symptoms of infection5Thomson PD, Smith DJ. What is infection? Am. J. Surg. 1994; 167(No. 1A): 7S-10S.,6Dow G, Browne A, Sibbald RG. Infection in chronic wounds: Controversies in diagnosis and treatment. Ostomy Wound Management 1999; 45 (8): 23-40..
Bacterial pathogenesis is undesirable since, at this stage, the wound is in a part of the wound infection continuum that typically requires intervention.
WOUNDCHEK™ Bacterial Status — Now available in countries accepting CE mark!
Posters & Articles
Serena, T. et al. 2015. Bacterial proteases: A marker for a 'state of pathogenesis' in chronic wounds
Wound Infection in Clinical Practice, International Wound Infection Institute, 2016
BPA Made Easy Wounds International, Serena T., et al, 2016
The Use of a point-of-care test for bacterial protease activity in chronic wounds Wounds International 2015, Vol 6 Issue 4
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